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10.1152/physrev.00013.2014 22 SmeekensS

Beglinger S, Drewe J, Schirra J, Gke B, D'Amato M, Beglinger C

Although the two active forms have shown equal biological potency, the majority of circulating GLP-1 in humans is found in the amidated form

Providers must weigh potential metabolic benefits against the risk of compounded side effects, altered medication absorption, or unmeasured interactions

The compounding process itself is less regulated than FDA-approved manufacturing
