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Keywords: central nervous system, anorexic medications, sympathetic nervous system, chronic heart failure Introduction Type 2 diabetes mellitus (T2DM) and obesity are major public health problems affecting millions of people worldwide

Wu L, Olverling A, Huang Z, Jansson L, Chao H, Gao X, Sjoholm A: GLP-1, exendin-4 and C-peptide regulate pancreatic islet microcirculation, insulin secretion and glucose tolerance in rats

New injectable GLP-1s are advancing through clinical trials, with CagriSema (cagrilintide/semaglutide) among the most advanced, showing greater weight loss than semaglutide and expected to seek approval in late 2025

Additionally, the nuclear transcription factor (Foxo1) is phosphorylated upon activation of phosphoinositide- 3-kinaseprotein kinase B/Akt (PI3 K-PKB/Akt), which in turn deactivates molecules to restrict the activity of proapoptotic pathways [66]

As relatively new classes of diabetes medications, GLP-1RA and SGLT2 agents are available as branded products with no generic equivalents