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These include the transcription factor PGC1 (peroxisome proliferator-activated receptor- coactivator), which is activated as a result to stimulate mitochondrial biogenesis among other cellular processes, members of the FOXO family of transcription factors, resulting in downstream beneficial effects on glucose metabolism and insulin signalling, and NF-, with consequent tempering of pro-inflammatory pathways 7

Liraglutide and exenatide were reported to induce apoptosis and autophagy through the AMPK signaling pathway, inhibiting the progression of endometrial cancer (216, 217)

Committing to long-term lifestyle changes is crucial to sustainable weight loss and well-being
