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The FTO gene - often referred to as the "obesity gene" - influences hunger and satiety, making individuals with certain variants more prone to overeating

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"A rapid reduction in fat can cause skin to sag, accentuating features associated with aging, such as jowls, loose skin on the neck and a sunken appearance around the eyes." Though not everyone on a GLP-1 will experience skin sagging, according to a recent article from the Cleveland Clinic, "the faster you lose weight, the more likely you are to experience" facial skin sagging

Moreschi, C