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In patients with HFpEF and obesity, both semaglutide (STEP-HFpEF) and tirzepatide (SUMMIT) significantly reduced cardiovascular death and worsening heart failure events, with concomitant improvements in quality of life and functional capacity [3,47]

Exercise alone maintained lean mass and preserved hip and spine BMD

Saxenda should be used as part of a long-term weight management plan that includes a reduced-calorie diet and increased exercise

Obesity in IBD: epidemiology, pathogenesis, disease course and treatment outcomes

These results support the rationale of developing retatrutide as an alternative to semaglutide and/or tirzepatide 5