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The results showed that obese individuals had lower availability of dopamine D2 receptors in the brain compared to non-obese individuals

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Importantly, while weight loss was observed in these trials, the degree of improvement in cardiac outcomes were often disproportionate to the weight reduction alone, suggesting at weight loss-independent mechanisms 30,31,44

Cardiovasc Diabetol 22 , 79 (2023)

But to be on the safe side, systemic hormone therapy is generally not advised for women who have a history of breast cancer, especially if theyre hormone receptor positive
