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N Engl J Med 2022;387:20516.ArticlePubMed 10

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Lifestyle Factors That Support GLP-1 Production Your broader lifestyle may also shape how well your body produces and responds to GLP-1, including: Exercise: Both human and animal research shows aerobic activity may increase GLP-1 secretion, and consistent movement also supports gut microbiome health, which may further support L-cell hormone release

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Metabolism 161:156057 Scheen AJ (2025) GLP-1 receptor agonists, body composition, skeletal muscle and risk of sarcopaenia: from promising findings in animal models to debated concern in human studies