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As you lose weight with semaglutide GLP-1 , you will experience a reduction in body fat, including the fat stored in the abdominal region

These results indicate that the impact of tirzepatide on gastric emptying is like that of selective GLP-1 receptor agonists [117]

However, its use in the general population for weight management or body composition enhancement is not supported by sufficient evidence and falls outside its licensed indications in all countries where it holds authorisation

The mechanism is indirect, primarily driven by rapid weight reduction and nutritional deficiencies rather than direct drug effects

doi: 10.2967/jnumed.121.263194