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Systematic evaluation of glucose control, body mass index, blood pressure, insulin secretion and insulin resistance is leveraged to identify patients who are likely to receive the greatest metabolic benefit from common antidiabetic drugs.

These data unveil a new central role for GIPR signaling and identify a potentially important cell type expressing both GLP-1R and GIPR upon which tirzepatide or other dual agonists may modulate DA homeostasis in the brain.

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