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The gradual decline in semaglutide levels means that both the therapeutic effects and any side effects will diminish progressively over several weeks rather than stopping abruptly

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Seek medical help if constipation lasts more than a few days or is accompanied by pain, vomiting, or bleeding, as these can indicate more serious digestive complications

Tirzepatide produced 20.2% weight loss versus 13.7% for semaglutide at 72 weeks and has stronger body-composition results