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The four micronutrients at greatest risk on a calorie-restricted GLP-1 diet are: Vitamin B12 essential for energy production, nerve function, and red blood cell formation

Because oral options sit directly within the stomach to be absorbed, some patients report a higher frequency of upper gastrointestinal symptoms, including acid reflux, indigestion, and localised stomach discomfort during the morning fasting window

The metformin concentration in the jejunum peaks at 500 g/g, 30300 times greater than plasma concentrations [13], highlighting the small intestine as an important site of metformin uptake