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The potential benefits of semaglutide 1 mg once weekly in people with atherosclerosis and peripheral artery disease (Figs 3, 4) are being examined over 52 weeks, with the primary outcomes of treadmill walking distance and secondary outcomes of changes in quality of life and pain free walking distance (NCT04560998)

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The logic is that more frequent, smaller doses create a more stable blood level of tirzepatide throughout the week, potentially reducing side effects further while maintaining more consistent receptor activation

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