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Anti-obesity drugs mainly act by targeting the central nervous system to suppress appetite or the gastrointestinal system to hinder absorption [8], typically administered orally or by injection

When you stop the medication, appetite tends to return, and without the pharmacological appetite suppression, a significant portion of lost weight typically comes back unless behavioral habits are strongly maintained

Sculptra builds gradually over 46 weeks to months

Therefore, modeling approaches can be valuable for examining the extent of pharmacokinetic DDIs driven by these mechanisms