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Almost 60 percent of adults have said they have heard at least some about these drugs, according to a 2024 KFF Health Tracking Poll

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Cardiovascular Outcomes Liraglutide (LEADER trial): 13% reduction in major adverse cardiovascular events (MACE) in patients with Type 2 diabetes and high cardiovascular risk Statistically significant cardiovascular protection Semaglutide (SELECT trial): 20% reduction in MACE in patients with obesity and established cardiovascular disease Studied specifically for cardiovascular outcomes in obesity (not just diabetes) Both medications provide cardiovascular protection, but semaglutides evidence is more recent, more robust, and specifically applicable to patients with obesity regardless of diabetes status

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As previously mentioned, two GLP-1 RAs are available for the management of weight even in patients who do not have diabetes [33, 34]

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More noticeable weight loss often develops over the following months as the medication continues working alongside healthy lifestyle habits

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