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GLP-1 also affects food intake, body weight, and has direct effects on the heart (52, 103)

Results of the first phase 3 trial comparing orforglipron with oral semaglutide found that patients with diabetes lost on average 6-8% of their body weight with orforglipron, compared with 4-5% on semaglutide

Authors contributions Substantive scientific and intellectual contributions to the study: Conception and design: Jos A
