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Description
To further implement GLP-1RA-centric combination therapy, we need to consider some evidence gaps (Table 4)

GLp-1 receptor agonists and risk for cirrhosis and related complications in patients with metabolic dysfunction-associated steatotic liver disease
Native human GLP-1 functions in a glucose-dependent manner, increasing insulin secretion and decreasing glucagon secretion in the presence of elevated blood glucose [8, 9]

In WT mice, systemic inhibition of DPP-4 activity, which inhibited plasma DPP-4 activity by about 90%, improved lipid tolerance and increased plasma active GLP-1 levels by approximately 4.5-fold in HFD-fed mice (Figure 5)

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