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Evidence of direct depletion: Weak Mechanistic plausibility via reduced intake: Moderate Symptoms of B12 Deficiency Neuropathy Fatigue Brain fog Macrocytic anaemia Persistent fatigue during GLP-1 therapy can have multiple causes, including caloric restriction and micronutrient shifts

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However, lasting results typically happen gradually over several months of consistent use and healthy lifestyle changes

Many other important enzymes like DPP-4, hormones such as glucagon, growth hormone, epinephrine, cortisol, sex hormones, and thyroid hormones and other pathways also impact blood sugar and insulin balance