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GIPR is expressed at low levels in some immune cells, predominantly in subsets of T cells and macrophages [139]

Materials and Methods Animals C57BL/6J DIO male mice aged between 21-24 weeks were purchased from Jackson Laboratories and used throughout this study

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For example, in experimental murine studies of obesity-related insulin resistance, an increased loss of muscle mass occurs via insulin receptor substrate-1/phosphatidylinositol-3-kinase Akt pathway down-regulation 47