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Berberine has become popular because social media often calls it a natural weight-loss option

27 Effects on glycemic control The primary end point in the RCTs SUSTAIN 15 was the change in glycosylated hemoglobin (HbA 1c ) from baseline until the end of the treatment

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Meta-analyses of randomised controlled trials (RCTs) also confirm that energy-restricted MD interventions yield greater weight loss than control or low-fat diets, particularly when combined with increased physical activity [116]
