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Today, Lexicon announced the publication of preclinical data validating ACSL5 as a target for obesity and chronic weight management
The effect on stroke is remarkable (and was significant in the trials of both semaglutide and dulaglutide), amounting to an 18% risk reduction, also because the other class of new antidiabetic agents with cardiovascular benefits, the SGLT2-inhibitors, show no a similar effect on stroke (but do have a significant effect on heart failure) [24]
It recruits Parkin for downstream ubiquitin clearance of the damaged mitochondria, also known as mitophagy
