novo nordisk's wegovy reduces cardiovascular risk more than lilly's tirzepatide shown to reduce of heart attack, stroke in major trial Weight-loss drug Wegovy produces 'largest

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Semaglutide is often optimized to maximize weight loss, yet it remains unclear whether long-term cardiovascular benefit is more closely associated with achieved weight reduction or therapeutic exposure

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Cardiometabolic Markers Secondary endpoints in published trials have included blood pressure, lipid panel, and inflammatory markers, giving researchers additional data points for modeling broader cardiometabolic effects of triple agonism