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Gut bacterial therapies that improve insulin sensitivity by altering the composition of the gut microbiota have become a new therapeutic modality

In this respect, the dual agonist effect of tirzepatide seems to give it a superiority on semaglutide, with a greater decrease (more than 2%) in glycated hemoglobin (A1c), a marker of chronic hyperglycemia (Figure 4)

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Available online at: (Accessed May 5, 2025)

using in vivo fiber photometry demonstrated that both GIP and GLP-1 analogs at pharmacologic doses inhibited AgRP neurons in proportion to their anorexigenic action