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A meta-analysis [74] including the ELIXA [66], LEADER [44], SUSTAIN-6 [67], EXSCEL [68], REWIND [70], and AMPLITUDE-O [51] studies found that GLP-1RAs were associated with better renal outcomes: a 30% or 40% or more decrease in glomerular filtration rate, need for renal replacement therapy, end-stage renal failure, or death from kidney disease by 21%

The planned treatment analysis includes everyone assigned to a dose group regardless of whether they completed titration

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[DOI] [PubMed] [Google Scholar] 3.Alvarez J.I., Katayama T., Prat A