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A head-to-head comparison revealed that both semaglutide and tirzepatide reduced the composite risk of hospitalization for HF or all-cause mortality by over 40% relative to placebo, with no significant advantage of tirzepatide over semaglutide

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A Strength of recommendation (SOR) A Good-quality patient-oriented evidence B Inconsistent or limited-quality patient-oriented evidence C Consensus, usual practice, opinion, disease-oriented evidence, case series The "Standards of Medical Care in Diabetes" guidelines published in 2015 by the American Diabetes Association (ADA) state that metformin is the preferred initial pharmacotherapy for managing type 2 diabetes

Key markersincluding GIPR rs1800437, GLP1R rs6923761, FTO rs9939609, and MC4R rs17782313predict which compounds and dosing strategies will produce optimal outcomes for each patient

Inzucchi, S