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The Weight Regain Question This is one of the hardest conversations in obesity medicine, and it's one that should happen before starting therapy, not after

Theyre simply too big to get through the skin barrier, which is designed to keep larger substances out

doi: 10.1016/j.apsb.2024.03.011 [DOI] [PMC free article] [PubMed] [Google Scholar] 105.Apperloo EM, Neuen BL, Fletcher RA, et al
As for long-term use, these medications are generally well-tolerated for extended periods

2025;8(1):e2457232-e
