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Under high-glucose and high-lipid stress, GLP-1RAs reduce apoptosis and mitigate mitochondrial dysfunction in human microvascular endothelial cells by inhibiting ERK1/2, JNK and p38 pathways, while suppressing caspase-3 and PARP cleavage (167)

The activation of GLP-1R can reduce the size of cerebral infarction by enhancing cell survival signaling pathways, reducing ischemia-reperfusion injury, promoting brain repair, and inhibiting inflammatory response and oxidative stress ( 4.4 Tumors The role of GLP-1RA in tumor remains controversial

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General Metabolic Health Optimization Health-conscious individuals already implementing solid nutrition and exercise habits might use these supplements for marginal metabolic gains

Risk of disease progression or death was cut by 28%