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It acts directly on several target tissues, including skeletal muscle and bone, but several effects are mediated indirectly by circulating (liver-derived) or locally produced IGF-1

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A phenomenon of reverse epidemiology has been observed, where lower cholesterol levels and lower BMI paradoxically correspond with higher mortality rates in PD populations [77,78,79]

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liraglutide enhances autophagy and promotes pancreatic cell proliferation to ameliorate type 2 diabetes in high-fat-fed and streptozotocin-treated mice
