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Robert Kushner was the lead investigator of the huge phase 3 clinical trial that evaluated the safety and effectiveness of semaglutide

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Recently, interest has grown in whether glucagonlike peptide1 receptor agonists (GLP1 RAs)a class of drugs commonly used to manage diabetes and obesitycould help reduce airway inflammation

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GLP-1 receptor agonists exert their therapeutic effects through several mechanisms : they stimulate insulin secretion from pancreatic beta cells in a glucose-dependent manner, suppress glucagon release (which reduces hepatic glucose production), slow gastric emptying, and act on appetite centres in the hypothalamus to promote satiety and reduce food intake