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glp-1 leptin The gut microbiota regulates hypothalamic inflammation and sensitivity in Western diet-fed mice via a GLP-1R-dependent mechanism: Cell Reports Investigating the Physiologic Role of
Description
This pharmacological effect, while beneficial for glycemic control and weight loss, may exacerbate gastrointestinal symptoms in individuals with active or poorly controlled celiac disease
The GLP1Rs were located at the cell membrane (Figure 3a)

13 Although evidence suggests that GLP-1 RAs may have neuroprotective properties and delay disease progression, this was based on a few small phase II studies

PMCID: PMC7112980

It's very difficult to get that person up and moving
