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To view or add a comment, sign in Olezarsen for Managing Severe Hypertriglyceridemia and Pancreatitis Risk In two phase 3, randomized, placebo-controlled trials (CORE-TIMI 72a and CORE2-TIMI 72b), monthly injections of olezarsenan antisense oligonucleotide (ASO) targeting apolipoprotein C-III (ApoC-III)produced robust, placebo-adjusted reductions in triglyceride levels at 6 months, reaching up to 72.2 percentage points with the 80 mg dose, and significantly greater proportions of patients achieved triglycerides below clinically relevant thresholds compared to placebo

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Iordache, A

This data is valuable for research integrity and for identifying individual variability in cardiovascular response to retatrutide

Hydration recommendations form the cornerstone of prevention: Fluid intake targets : Patients should aim for sufficient fluid intake to produce at least 2.5 liters of urine daily, in accordance with American Urological Association guidelines