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Description
Rapid dose escalation increases risk significantly

doi: 10.1097/GOX.0000000000005516

Application of exendin-4 depolarizes the membrane potential and increases the spontaneous discharge rate of orexinergic neurons in the lateral hypothalamus (Acuna-Goycolea and van den Pol, 2004)

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We can see from the prescribing documentation for Wegovy that there were at least three randomized, double-blind, placebo-controlled trials with adults for this medication
