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The decades of research on CR suggest that the reduction in cancer incidence in CR is facilitated by the reduction in glucose, insulin, and IGF-1 levels, which would otherwise stimulate cell growth and proliferation, and the reduction in oxidative stress and inflammation (49, 50)

KEGG pathway analysis has revealed that the MAPK, PI3K and Wnt pathways are involved in this process (197, 198)

Similarly, Chen et al

Treatment satisfaction in people with type 2 diabetes mellitus treated with once-weekly dulaglutide: data from the AWARD-1 and AWARD-3 clinical trials

The results from these showed that synergism between these compounds might be responsible for the results observed in the yerba mat intervention group