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After discontinuation, there was a pronounced rebound in weight (MD=4.13 kg, 95% CI: 1.60 to 6.65), BMI (MD=0.84 kg/m2, 95% CI: 0.37 to 1.32), WC (MD=3.64 cm, 95% CI: 2.27 to 5.01), and HbA1c (SMD=0.69, 95% CI: 0.50 to 0.89)

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According to the 2024 World Obesity Report, the global prevalence of obesity is steadily increasing, with projections indicating that by 2035, over half of the world's population will be classified as overweight [1]

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