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Injectable tirzepatide will likely remain the gold standard for maximum weight loss for the foreseeable future, while oral options serve different patient populations and treatment phases

Until approval decisions are made, legitimate access is limited to appropriate clinical-trial participation

Limitations include that the data came from 1 health system in the US, most patients were white, and it was unknown why patients were prescribed this medication, although 93% were diabetic

Additionally, it is reasonable to consider that the decreased fracture risk in the exposure group of our study is multifactorial, with factors including weight loss resulting from being prescribed GLP-1 RA and increased motivation to adopt a healthier lifestyle

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