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However, when combined with GLP-1 activity, the glucagon effects shift toward thermogenesis and fat oxidation rather than hyperglycemia
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The Journal of Clinical Investigation, 117, 143152

When appetite is suppressed, individuals often gravitate towards easily consumed foods, which may be carbohydrate-heavy and protein-poor

Then came tirzepatide, a dual agonist that targets both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors
