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Intestinal OCT1 transport and GI intolerance with metformin Given the role of OCT1 in potentially altering local concentrations of metformin, our group (Dujic et al) proposed that a reduction in function of OCT1 might alter the risk of GI intolerance in patients treated with metformin [7]

Thus, there is a highly unmet medical need to ameliorate hyperphagia and obesity related to POMC-MC4R pathway deficiency

Discontinue GLP-1 agonist immediately

While GLP1 drugs offer substantial benefits, they are not without limitations

[15] [7] Factors That Affect How Quickly GLP-1 Takes Effect Several individual and medication-specific factors influence how rapidly you'll experience the benefits of GLP-1 therapy: Medication formulation and dosing frequency play a significant role