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Likely because of the cost and technological considerations, FDA expected that generic manufacturers would pursue solid state peptide synthesis

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J Lipid Res (2006) 47(12):272637.10.1194/jlr.M600299-JLR200 131 OzcanUCaoQYilmazELeeAHIwakoshiNNOzdelenEet alEndoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes