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PCSK2) is highly expressed in the pancreas [151], and its expression in -cells results in cleavage of Gcg into pancreatic type glucagon, GRPP, MPGF, and a small intervening peptide (IP1)

Gastrointestinal adverse events (nausea, vomiting, diarrhea) are fairly common while pancreatitis and intestinal obstruction are rarer
