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Higher mean age and baseline SBP, greater use of anti-hypertensive medications, longer T2D duration, and reduction in insulin daily dose might have contributed to explain the difference observed in the impact of weight loss on SBP reduction in these trials, although direct GLP-1R- and GIP-R-mediated effects could also be considered [77]

Pennsylvania (Independence Blue Cross) Independence Blue Cross, serving the greater Philadelphia region, had spent $500 million on GLP-1 medications, up 45 percent from the prior year

Gradual dose escalation improves gastrointestinal tolerability.78 Acute pancreatitis is a rare but documented adverse event associated with exenatide use, as reported in the FDA Adverse Event Reporting System and observational studies.79 Current guidelines from the American Association of Clinical Endocrinologists recommend cautious use of GLP-1RAs in T2DM patients with a history of pancreatitis80 (See Figures 2 and 3)

Retatrutide emerges as a promising multi-pathway therapeutic, attracting significant clinical interest for its potent effects on weight loss and metabolic control

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