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However, assessment of body composition in both of these studies revealed that the absence of GIPR signaling in adipocytes contributes to reduced lean mass, but not fat mass
Cardiovascular Risk Reduction# Recommendation : Semaglutide Reason : SELECT demonstrated 20% MACE reduction with semaglutide in 17,604 patients
For safety outcomes, semaglutide and tirzepatide showed lower risks for serious bacterial infections compared to sitagliptin and dulaglutide, respectively
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