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These areas contain sufficient subcutaneous tissuethe layer between skin and musclewhere the medication dissolves gradually into the bloodstream

A multi-branched gatekeeping testing procedure was used to account for multiple comparisons among the primary and key secondary end points in PIONEER 1 to 4, and 8 and a simple hierarchical testing procedure was used in PIONEER 5 and 6, both of which were appropriate methods of control for multiplicity

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Now, seeing the dramatic effects of mitigating cortisol, they are starting to re-evaluate those assumptions
