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Tirzepatide BNF monograph (includes MHRA/CHM advice on GLP-1 receptor agonists and pancreatitis)

The study, published in JAMA Ophthalmology on 5 June 2025, reported a low but substantially higher risk of being diagnosed with nAMD among patients exposed to GLP-1 RAs, compared with those who were not

"These data are the first to show the combined use of tirzepatide and menopause hormone therapy significantly increases treatment effectiveness in postmenopausal women," said Dr Regina Castaneda, research fellow for the Division of Endocrinology at the Mayo Clinic in Jacksonville

Patients need to work closely with their healthcare provider to monitor progress and ensure that they are following the most appropriate treatment plan for their unique health needs

The presence of small amounts of sugars (like sucrose) helps stabilize the peptide, as their hydrogen bonds mimic those of water and reduce moisture-related collapse