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Cinnamaldehyde-curcumin-BBR formulations (F2) enhance Akt2 phosphorylation (T450, Y475, and S474), improving insulin sensitivity without adipogenic effects in diet-induced obese mice [192, 193]

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Despite propensity-score matching and two complementary post-PSM analyses (a diabetes-severity model and an active-comparator design), platform constraints on the number of covariates and unmeasured factors mean that residual biasincluding potential immortal-time/time-origin biascannot be entirely excluded