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By activating both GIP and GLP-1 receptors, tirzepatide enhances insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and reduces appetite through central nervous system pathways

A meta-analysis published in 2025 (which analyzed multiple studies together) found that tirzepatide reduced hsCRP, a marker of systemic inflammation, by 32.9% and IL-6 by 17.8% (2)

Plus, fiber often shows up in foods that are lower in calories, such as fruits and vegetables, so you feel fuller even though youre consuming fewer calories

These limits should be considered maximum thresholds rather than recommendations, and lower consumption is generally safer