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Acknowledgements All authors have made substantial contributions to all the following: (1) the conception and design of the study, or acquisition of data, or analysis and interpretation of data, (2) drafting the article or revising it critically for important intellectual content, (3) final approval of the version to be submitted

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Investigational: Why This Difference Matters FDA approval means a medication has gone through a regulatory review process for specific uses, dosing, labeling, safety information, manufacturing standards, and prescribing instructions

Actual Medication Cost Per Dose Approximate Compounding Costs: While providers dont break this down, approximate pharmaceutical costs: Per Dose (Wholesale to Pharmacy): 2.5 mg dose: ~$15-25 5 mg dose: ~$25-40 7.5 mg dose: ~$35-55 10 mg dose: ~$45-70 12.5 mg dose: ~$55-85 15 mg dose: ~$65-100 Monthly Medication Cost (4 doses): 2.5 mg weekly: ~$60-100/month 5 mg weekly: ~$100-160/month 7.5 mg weekly: ~$140-220/month 10 mg weekly: ~$180-280/month 12.5 mg weekly: ~$220-340/month 15 mg weekly: ~$260-400/month Additional costs for providers: Medical consultation/oversight: ~$50-100/month allocated Supplies (syringes, sharps, pads): ~$10-20/month Shipping and handling: ~$15-25/month Customer support and operations: ~$30-50/month Platform/technology costs: ~$20-40/month Total provider cost: ~$250-400/month at maximum doses Provider pricing of $349-$699/month represents reasonable to premium margins over actual costs

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