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Whether the positive impact of GLP-1RAs on hepatic histology is indirect, i.e., through their action on extrahepatic tissues, or whether their action is direct, i.e., through activating GLP-1R on the hepatocytes, is still a controversial issue

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A synthesis method and technology of semaglutide, applied in the field of polypeptide drug production, can solve the problems of high separation and purification, limited coupling site, purification of polypeptide fragments, etc., and achieve the solution of purification difficulty, alleviation of difficulty and rapid transformation