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After treatment with GLP-1, the number of apoptotic cells drastically reduced in the human isolated islets

Large cardiovascular outcome trials (e.g., Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER), SUSTAIN) and post-marketing surveillance have not demonstrated an increased incidence of MTC in humans, though long-term pharmacovigilance continues given the rarity of this malignancy [30,62]

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They are still being studied and are not yet FDA-approved

Liraglutide, semaglutide and tirzepatide are the three drugs on the market