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Description
Safety and efficacy of apitegromab in patients with spinal muscular atrophy types 2 and 3: the phase 2 TOPAZ study

The starting dose is administered for the first 4 weeks, on the same day each week and at the same time

The primary objective was weight loss

While both target weight loss and metabolic health, they differ meaningfully in how they affect appetite, fat loss, insulin sensitivity, and long-term metabolic signaling

Simply inject at your usual local time in the new time zone
