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All dosages of danuglipron significantly reduced patients HbA1c and fasting blood glucose levels, with more pronounced weight loss effects observed in the 80 mg and 120 mg doses compared to the placebo group

However, the data presented here in conjunction with clinical data on this mechanism in ALS suggests that it may not be of value to perform clinical studies with GLP-1 agonists in ALS and that resources may be more usefully focussed elsewhere

Visceral abnormalities occurred in blood vessels, lung, liver, and esophagus

Patients from the group receiving GLP-1 receptor agonists experienced less weight gain, with some of them even losing weight in comparison to the control group, Xavier said

Rising utilization and costs The high cost is driven not only by the price of these drugs, but also by their expanded use for other conditions associated with cardiometabolic disease, such as obstructive sleep apnea