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His reasoning was elegant: if he could identify hormone-like compounds in animals with unusual metabolic adaptations, those molecules might reveal something about human physiologyor even become therapeutic agents themselves
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The proteolytic stability to NEP 24.11 could predict mostly the results in mouse plasma

For instance, atrasentan, an ERA, reduced kidney outcome risk by 35% but was also associated with a non-significant increase in hospitalization for HF [16]

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